Meerssen's most important building is the St. Bartholomeus, a big church in Mosan Gothic style. Most of the church dates from the 14th century, but in 1936-1938 it was lengthened by architect Jos. Cuypers and his son Pierre jr..

From 1633 until 1802 the St. Bartholomeus was divided in a catholic and a protestant part. In 1836, when Meerssen was part of Belgium, this so-called simultaneum was ended, and the Belgium government gave the protestants this reformed church in neo-Classical style as compensation. Such churches are called Leopoldskerken ('Leopold churches') in Dutch, after the Belgian king of that time.

Jos. Cuypers spent his last years in Meerssen. One of his last designs is this Vredeskapel ('peace chapel') which was built in 1942 for the convent of St Joseph.

The former town hall is a building in neo-Gothic style which was designed by C. Weber and built in 1867.

The Regout family tomb is a neo-Gothic chapel-like building from 1869. Petrus Regout founded the Sphinx ceramics facory in Maastricht but preferred to be buried in Meerssen, due to a conflict with the Maastricht city-counsil.